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The Application of Mass Spectrometry in Drug Metabolism and Pharmacokinetics

Authors
Lee, Ji-YoonKim, Sang KyumLee, KihoOh, Soo Jin
Issue Date
2021
Publisher
SPRINGER-VERLAG SINGAPORE PTE LTD
Keywords
Drug discovery; Drug metabolism; Mass spectrometry; Pharmacokinetics
Citation
ADVANCED IMAGING AND BIO TECHNIQUES FOR CONVERGENCE SCIENCE, v.1310, pp.533 - 550
Indexed
SCIE
SCOPUS
Journal Title
ADVANCED IMAGING AND BIO TECHNIQUES FOR CONVERGENCE SCIENCE
Volume
1310
Start Page
533
End Page
550
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/130085
DOI
10.1007/978-981-33-6064-8_20
ISSN
0065-2598
Abstract
Drug metabolism and pharmacokinetics (DMPK) are fundamental in drug discovery. New chemical entities (NCEs) are typically evaluated with various in vitro and in vivo assays, which are time-consuming and labor intensive. These experiments are essential in identifying potential new drugs. Recently, mass spectrometry (MS) has played a key role in examining the drug-like properties of NCEs. Quantitative and qualitative mass spectrometry approaches are routinely utilized to obtain high-quality data in an efficient, timely, and cost-effective manner. Especially, liquid chromatography (LC) coupled with MS technology has been refined for metabolite identification (Met ID), which is critical for lead optimization. These qualitative and quantitative MS approaches and their specific utility in DMPK characterization will be described in this chapter. © 2021, Springer Nature Singapore Pte Ltd.
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