Impact of stent designs ofsecond-generation drug-elutingstents on long-term outcomes in coronary bifurcation lesions
- Authors
- Jang, Woo Jin; Chun, Woo Jung; Park, Ik Hyun; Choi, Ki Hong; Song, Young Bin; Koo, Bon-Kwon; Doh, Joon-Hyung; Hong, Soon-Jun; Nam, Chang-Wook; Gwon, Hyeon-Cheol
- Issue Date
- 2021
- Publisher
- WILEY
- Keywords
- coronary bifurcation lesion; percutaneous coronary intervention; second-generation drug-eluting stent
- Citation
- CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, v.98, no.3, pp.458 - 467
- Indexed
- SCIE
SCOPUS
- Journal Title
- CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
- Volume
- 98
- Number
- 3
- Start Page
- 458
- End Page
- 467
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/130129
- DOI
- 10.1002/ccd.29137
- ISSN
- 1522-1946
- Abstract
- Objectives We compared the long-term clinical outcomes of four different types of second-generation drug-eluting stents (DESs) in coronary bifurcation lesions. Background Clinical outcomes of different designs of second-generation DESs are not well known in bifurcation lesions. Methods Patients who underwent percutaneous coronary intervention with second-generation DESs for coronary bifurcation lesion were enrolled from 21 centers in South Korea. A total of 2,526 patients was evaluated and divided into four treatment groups according to DES type: bioabsorbable polymer biolimus-eluting stent (BP-BES group,n= 514), platinum chromium everolimus-eluting stent (PtCr-EES group,n= 473), cobalt nickel zotarolimus-eluting stent (CoNi-ZES group,n= 736), or cobalt chromium everolimus-eluting stent (CoCr-EES group,n= 803). Primary outcome was target lesion failure (TLF, defined as a composite of cardiac death, target vessel myocardial infarction, or target lesion revascularization). Inverse probability of treatment weighting (IPTW) was performed to reduce selection bias and potential confounding factors. Results For 5 years of follow-up, the rates of TLF among the four DES groups were not significantly different (6.2% for BP-BES group, 8.2% for PtCr-EES group, 6.5% for CoNi-ZES group, and 8.6% for CoCr-EES group,p= .434). The results were consistent after IPTW adjustment (6.8, 8.4, 6.0, and 7.5%, respectively,p= .554). In subgroup analysis, the similarity of long-term outcomes among the four different types of second-generation DES was consistent across subgroups regardless of side branch treatment (pfor interaction = .691). Conclusion There seems to be no significant difference in long-term clinical outcomes among patients who received different types of second-generation DES for coronary bifurcation lesion.
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