Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Neuroprotective effect ofAllium hookeriagainst H2O2-induced PC12 cell cytotoxicity by reducing oxidative stress

Authors
Rho, Sang HoYou, SoHyeonKim, Gun-HeePark, Hyun Jin
Issue Date
11월-2020
Publisher
KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
Keywords
Allium hookeri; Antioxidant; Neuro-protection; Phenolics; Flavonoids
Citation
FOOD SCIENCE AND BIOTECHNOLOGY, v.29, no.11, pp.1519 - 1530
Indexed
SCIE
SCOPUS
KCI
Journal Title
FOOD SCIENCE AND BIOTECHNOLOGY
Volume
29
Number
11
Start Page
1519
End Page
1530
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/130407
DOI
10.1007/s10068-020-00805-8
ISSN
1226-7708
Abstract
In this study, the anti-oxidative and neuro-protective effects of ethanolic extracts of the dried roots ofAllium hookeriwere investigated. Total phenolic contents and total flavonoid contents ofA. hookeriextract depended on the ethanol concentrations used (50, 70 and 95%). In order to evaluate radical scavenging activity, DPPH and ABTS radical scavenging assays and ferric reducing powers were evaluated. The results showed the 95% ethanol extract ofA. hookeri(95AH) had higher phenolic and flavonoid contents, and greater radical scavenging activities than 50 or 70% ethanol extracts ofA. hookeri. The neuro-protective effects of 95AH were evaluated using H2O2-treated PC12 neuronal cells. Treatment of 95AH increased cell viability and superoxide dismutase and glutathione peroxidase activities, reduced lactate dehydrogenate release, reduced reactive oxygen species production, and increased Bcl-2/Bax ratio. HPLC revealed 95AH was rich in phenolics, especially catechin. These results demonstrate 95AH has substantial anti-oxidative and neuro-protective effects against H2O2-induced oxidative stress.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Life Sciences and Biotechnology > Division of Food Bioscience and Technology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher PARK, HYUN JIN photo

PARK, HYUN JIN
생명과학대학 (식품공학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE