Early Post-Rewarming Fever Is Associated with Favorable 6-Month Neurologic Outcomes in Patients with Out-Of-Hospital Cardiac Arrest: A Multicenter Registry Study
- Authors
- Lee, Hyoung Youn; Lee, Dong Hun; Lee, Byung Kook; Jeung, Kyung Woon; Jung, Yong Hun; Choi, Seung Phil; Park, Jung Soo; Lee, Jae Hoon; Han, Kap Su; Min, Yong Il
- Issue Date
- 9월-2020
- Publisher
- MDPI
- Keywords
- out-of-hospital cardiac arrest; targeted temperature management; prognosis; fever
- Citation
- JOURNAL OF CLINICAL MEDICINE, v.9, no.9
- Indexed
- SCIE
- Journal Title
- JOURNAL OF CLINICAL MEDICINE
- Volume
- 9
- Number
- 9
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/130476
- DOI
- 10.3390/jcm9092927
- ISSN
- 2077-0383
- Abstract
- We investigated the association between post-rewarming fever (PRF) and 6-month neurologic outcomes in cardiac arrest survivors. This was a multicenter study based on a registry of comatose adult (>= 18 years) out-of-hospital cardiac arrest (OHCA) survivors who underwent targeted temperature management between October 2015 to December 2018. PRF was defined as peak temperature >= 38.0 degrees C within 72 h after completion of rewarming, and PRF timing was categorized as within 24, 24-48, and 48-72 h epochs. The primary outcome was neurologic outcomes at six months after cardiac arrest. Unfavorable neurologic outcome was defined as cerebral performance categories three to five. A total of 1031 patients were included, and 642 (62.3%) had unfavorable neurologic outcomes. PRF developed in 389 (37.7%) patients in 72 h after rewarming: within 24 h in 150 (38.6%), in 24-48 h in 155 (39.8%), and in 48-72 h in 84 (21.6%). PRF was associated with improved neurologic outcomes (odds ratio (OR), 0.633; 95% confidence interval (CI), 0.416-0.963). PRF within 24 h (OR, 0.355; 95% CI, 0.191-0.659), but not in 24-48 h or 48-72 h, was associated with unfavorable neurologic outcomes. Early PRF within 24 h after rewarming was associated with favorable neurologic outcomes.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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