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Binary Drug Reinforced First Small-Molecule-Based Prodrug for Synergistic Anticancer Effects
- Authors
- Jangili, Paramesh; Won, Miae; Kim, Seo Jin; Chun, Jieun; Shim, Inseob; Kang, Chulhun; Ren, Wen Xiu; Kim, Jong Seung
- Issue Date
- 19-8월-2019
- Publisher
- AMER CHEMICAL SOC
- Keywords
- binary drug; SN-38; 5' -DFUR; COX-2; synergistic effect
- Citation
- ACS APPLIED BIO MATERIALS, v.2, no.8, pp.3532 - 3539
- Indexed
- SCOPUS
- Journal Title
- ACS APPLIED BIO MATERIALS
- Volume
- 2
- Number
- 8
- Start Page
- 3532
- End Page
- 3539
- ISSN
- 2576-6422
- Abstract
- We developed a small-molecule-based binary drug delivery system (BDDS) with two anticancer drugs, SN-38 and 5'-DFUR. The drug release from the prodrug BDDS can be achieved upon its reaction with intracellular H2O2, overexpressed in cancer cells. The efficacy of BDDS was demonstrated by a comparative study along with that of a single drug conjugate (SDDS), bearing SN-38 alone.
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