Cruciferous vegetables and colorectal cancer prevention through microRNA regulation: A review
DC Field | Value | Language |
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dc.contributor.author | Pan, Jeong Hoon | - |
dc.contributor.author | Abernathy, Breann | - |
dc.contributor.author | Kim, Young Jun | - |
dc.contributor.author | Lee, Jin Hyup | - |
dc.contributor.author | Kim, Jun Ho | - |
dc.contributor.author | Shin, Eui Cheol | - |
dc.contributor.author | Kim, Jae Kyeom | - |
dc.date.accessioned | 2021-12-19T07:41:08Z | - |
dc.date.available | 2021-12-19T07:41:08Z | - |
dc.date.created | 2021-08-30 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1040-8398 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/132148 | - |
dc.description.abstract | Diets rich in fruits and vegetables may lower colorectal cancer risk. In particular, a number of in vitro and in vivo studies demonstrated that cruciferous vegetables and their active compounds elicit chemopreventive potency through multiple mechanisms. However, it is relatively unexplored whether these vegetables modulate the risk of cancer development through epigenetic mechanisms including noncoding RNAs. Therefore, the objective of the present review is to report and discuss existing evidence with regards to modulation of microRNAs (miRNAs), one variety of noncoding RNAs, by cruciferous vegetables and their chemo-preventive effects against colorectal cancers. As results, it seems clear, considering accumulating evidence regarding their interactions with cancer related genes and relevant signaling pathways, that miRNA modulation via cruciferous vegetables is an attractive target for the prevention of colorectal cancer. In addition, miRNAs have been characterized as diagnostic and prognostic biomarkers and utilized in cancer therapeutics. Thus, it is very possible that natural agents (not limited to those in cruciferous vegetables) enhance cancer therapeutic efficacy and elicit chemopreventive effects through modulating key miRNAs. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.subject | CELL-CYCLE ARREST | - |
dc.subject | CHEMOPREVENTIVE AGENT INDOLE-3-CARBINOL | - |
dc.subject | BRASSICA-OLERACEA | - |
dc.subject | DIETARY FIBER | - |
dc.subject | GLUCOSINOLATE CONTENT | - |
dc.subject | PANCREATIC-CANCER | - |
dc.subject | UP-REGULATION | - |
dc.subject | PHENETHYL ISOTHIOCYANATE | - |
dc.subject | MESENCHYMAL TRANSITION | - |
dc.subject | ADENOCARCINOMA CELLS | - |
dc.title | Cruciferous vegetables and colorectal cancer prevention through microRNA regulation: A review | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Young Jun | - |
dc.contributor.affiliatedAuthor | Lee, Jin Hyup | - |
dc.identifier.doi | 10.1080/10408398.2017.1300134 | - |
dc.identifier.scopusid | 2-s2.0-85020699518 | - |
dc.identifier.wosid | 000441731400006 | - |
dc.identifier.bibliographicCitation | CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, v.58, no.12, pp.2026 - 2038 | - |
dc.relation.isPartOf | CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION | - |
dc.citation.title | CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION | - |
dc.citation.volume | 58 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2026 | - |
dc.citation.endPage | 2038 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | CELL-CYCLE ARREST | - |
dc.subject.keywordPlus | CHEMOPREVENTIVE AGENT INDOLE-3-CARBINOL | - |
dc.subject.keywordPlus | BRASSICA-OLERACEA | - |
dc.subject.keywordPlus | DIETARY FIBER | - |
dc.subject.keywordPlus | GLUCOSINOLATE CONTENT | - |
dc.subject.keywordPlus | PANCREATIC-CANCER | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | PHENETHYL ISOTHIOCYANATE | - |
dc.subject.keywordPlus | MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | ADENOCARCINOMA CELLS | - |
dc.subject.keywordAuthor | Glucosinolates | - |
dc.subject.keywordAuthor | colorectal cancer | - |
dc.subject.keywordAuthor | cruciferous vegetables | - |
dc.subject.keywordAuthor | microRNA | - |
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