Lactobacillus plantarum K8-based paraprobiotics suppress lipid accumulation during adipogenesis by the regulation of JAK/STAT and AMPK signaling pathways
DC Field | Value | Language |
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dc.contributor.author | Kim, Hoon | - |
dc.contributor.author | Lim, Jeong-Ju | - |
dc.contributor.author | Shin, Hyun Young | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.contributor.author | Choi, Hyeon-Son | - |
dc.date.accessioned | 2022-02-12T22:40:22Z | - |
dc.date.available | 2022-02-12T22:40:22Z | - |
dc.date.created | 2022-02-09 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135550 | - |
dc.description.abstract | Paraprobiotics are non-viable cells or cell fractions that have beneficial effects on the host; they may help in overcoming the limitations of probiotics and expanding their benefits. Here, we aimed to investigate their effects on lipid accumulation and the underlying mechanisms in 3T3-L1 preadipocytes. A novel paraprobiotic, LAB-P, prepared from the live cells of Lactobacillus plantarum K8, effectively inhibited lipid accumulation during adipogenesis via downregulation of the key activators PPAR gamma and C/EBP alpha. LAB-P-mediated reduction of lipid accumulation regulated early adipogenic factors, including downregulation of C/EBPS, KLF4, KLF5, KROX20, and C/EBP8, and upregulation of DLK1. Western blotting analysis revealed that these inhibitory effects of LAB-P on adipogenesis were associated with regulating JAK-STAT and AMPK alpha signaling pathways. This study highlights the potential of paraprobiotics as a functional food material to control obesity or obesity-related diseases, and provides valuable groundwork for utilizing LAB-P as a functional ingredient to alleviate obesity or lipid accumulation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | TRANSCRIPTIONAL REGULATION | - |
dc.subject | STIMULATES ADIPOGENESIS | - |
dc.subject | GUT MICROBIOTA | - |
dc.subject | C/EBP-BETA | - |
dc.subject | METABOLISM | - |
dc.subject | ACTIVATION | - |
dc.title | Lactobacillus plantarum K8-based paraprobiotics suppress lipid accumulation during adipogenesis by the regulation of JAK/STAT and AMPK signaling pathways | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1016/j.jff.2021.104824 | - |
dc.identifier.scopusid | 2-s2.0-85118122227 | - |
dc.identifier.wosid | 000715048700003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF FUNCTIONAL FOODS, v.87 | - |
dc.relation.isPartOf | JOURNAL OF FUNCTIONAL FOODS | - |
dc.citation.title | JOURNAL OF FUNCTIONAL FOODS | - |
dc.citation.volume | 87 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | C/EBP-BETA | - |
dc.subject.keywordPlus | GUT MICROBIOTA | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | STIMULATES ADIPOGENESIS | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL REGULATION | - |
dc.subject.keywordAuthor | AMPK alpha | - |
dc.subject.keywordAuthor | Adipogenesis | - |
dc.subject.keywordAuthor | JAK/STAT | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Paraprobiotics | - |
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