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Lactobacillus plantarum K8-based paraprobiotics suppress lipid accumulation during adipogenesis by the regulation of JAK/STAT and AMPK signaling pathways

Authors
Kim, HoonLim, Jeong-JuShin, Hyun YoungSuh, Hyung JooChoi, Hyeon-Son
Issue Date
12월-2021
Publisher
ELSEVIER
Keywords
AMPK alpha; Adipogenesis; JAK/STAT; Obesity; Paraprobiotics
Citation
JOURNAL OF FUNCTIONAL FOODS, v.87
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF FUNCTIONAL FOODS
Volume
87
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/135550
DOI
10.1016/j.jff.2021.104824
ISSN
1756-4646
Abstract
Paraprobiotics are non-viable cells or cell fractions that have beneficial effects on the host; they may help in overcoming the limitations of probiotics and expanding their benefits. Here, we aimed to investigate their effects on lipid accumulation and the underlying mechanisms in 3T3-L1 preadipocytes. A novel paraprobiotic, LAB-P, prepared from the live cells of Lactobacillus plantarum K8, effectively inhibited lipid accumulation during adipogenesis via downregulation of the key activators PPAR gamma and C/EBP alpha. LAB-P-mediated reduction of lipid accumulation regulated early adipogenic factors, including downregulation of C/EBPS, KLF4, KLF5, KROX20, and C/EBP8, and upregulation of DLK1. Western blotting analysis revealed that these inhibitory effects of LAB-P on adipogenesis were associated with regulating JAK-STAT and AMPK alpha signaling pathways. This study highlights the potential of paraprobiotics as a functional food material to control obesity or obesity-related diseases, and provides valuable groundwork for utilizing LAB-P as a functional ingredient to alleviate obesity or lipid accumulation.
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Suh, Hyung Joo
보건과학대학 (바이오시스템의과학부)
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