GABA(A) Receptor-Mediated Sleep-Promoting Effect of Saaz-Saphir Hops Mixture Containing Xanthohumol and Humulone
DC Field | Value | Language |
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dc.contributor.author | Min, Byungjick | - |
dc.contributor.author | Ahn, Yejin | - |
dc.contributor.author | Cho, Hyeok-Jun | - |
dc.contributor.author | Kwak, Woong-Kwon | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.contributor.author | Jo, Kyungae | - |
dc.date.accessioned | 2022-02-13T15:41:21Z | - |
dc.date.available | 2022-02-13T15:41:21Z | - |
dc.date.created | 2022-01-19 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/135639 | - |
dc.description.abstract | Hops contain flavonoids that have sedative and sleep-promoting activities such as alpha-acid, beta-acid, and xanthohumol. In this study, the sleep-enhancing activity of a Saaz-Saphir hops mixture was measured. In the caffeine-induced insomnia model, the administration of a Saaz-Saphir mixture increased the sleep time compared to Saaz or Saphir administration alone, which was attributed to the increase in NREM sleep time by the delta-wave increase. Oral administration of the Saaz-Saphir mixture for 3 weeks increased the gamma-amino butyric acid (GABA) content in the brain and increased the expression of the GABA(A) receptor. As the GABA antagonists picrotoxin and bicuculline showed a decrease in sleep activity, it was confirmed that the GABA(A) receptor was involved in the Saaz-Saphir mixture activity. In addition, the GABA(A) receptor antagonist also reduced the sleep activity induced by xanthohumol and humulone contained in the Saaz-Saphir mixture. Therefore, xanthohumol and humulone contained in the Saaz-Saphir mixture showed sleep-promoting activity mediated by the GABA(A) receptors. The mixture of the Saaz and Saphir hop varieties may thus help mitigate sleep disturbances compared to other hop varieties. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | MAGNETIC-RESONANCE SPECTROSCOPY | - |
dc.subject | GAMMA-AMINOBUTYRIC-ACID | - |
dc.subject | PHARMACOLOGICAL PROFILE | - |
dc.subject | PRIMARY INSOMNIA | - |
dc.subject | DISTURBANCE | - |
dc.subject | CAFFEINE | - |
dc.title | GABA(A) Receptor-Mediated Sleep-Promoting Effect of Saaz-Saphir Hops Mixture Containing Xanthohumol and Humulone | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.3390/molecules26237108 | - |
dc.identifier.scopusid | 2-s2.0-85119972463 | - |
dc.identifier.wosid | 000734531700001 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.26, no.23 | - |
dc.relation.isPartOf | MOLECULES | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 26 | - |
dc.citation.number | 23 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | CAFFEINE | - |
dc.subject.keywordPlus | DISTURBANCE | - |
dc.subject.keywordPlus | GAMMA-AMINOBUTYRIC-ACID | - |
dc.subject.keywordPlus | MAGNETIC-RESONANCE SPECTROSCOPY | - |
dc.subject.keywordPlus | PHARMACOLOGICAL PROFILE | - |
dc.subject.keywordPlus | PRIMARY INSOMNIA | - |
dc.subject.keywordAuthor | GABA(A) receptor | - |
dc.subject.keywordAuthor | Saaz | - |
dc.subject.keywordAuthor | Sapir | - |
dc.subject.keywordAuthor | hop | - |
dc.subject.keywordAuthor | humulone | - |
dc.subject.keywordAuthor | xanthohumol | - |
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