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GABA(A) Receptor-Mediated Sleep-Promoting Effect of Saaz-Saphir Hops Mixture Containing Xanthohumol and Humulone

Authors
Min, ByungjickAhn, YejinCho, Hyeok-JunKwak, Woong-KwonSuh, Hyung JooJo, Kyungae
Issue Date
12월-2021
Publisher
MDPI
Keywords
GABA(A) receptor; Saaz; Sapir; hop; humulone; xanthohumol
Citation
MOLECULES, v.26, no.23
Indexed
SCIE
SCOPUS
Journal Title
MOLECULES
Volume
26
Number
23
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/135639
DOI
10.3390/molecules26237108
ISSN
1420-3049
Abstract
Hops contain flavonoids that have sedative and sleep-promoting activities such as alpha-acid, beta-acid, and xanthohumol. In this study, the sleep-enhancing activity of a Saaz-Saphir hops mixture was measured. In the caffeine-induced insomnia model, the administration of a Saaz-Saphir mixture increased the sleep time compared to Saaz or Saphir administration alone, which was attributed to the increase in NREM sleep time by the delta-wave increase. Oral administration of the Saaz-Saphir mixture for 3 weeks increased the gamma-amino butyric acid (GABA) content in the brain and increased the expression of the GABA(A) receptor. As the GABA antagonists picrotoxin and bicuculline showed a decrease in sleep activity, it was confirmed that the GABA(A) receptor was involved in the Saaz-Saphir mixture activity. In addition, the GABA(A) receptor antagonist also reduced the sleep activity induced by xanthohumol and humulone contained in the Saaz-Saphir mixture. Therefore, xanthohumol and humulone contained in the Saaz-Saphir mixture showed sleep-promoting activity mediated by the GABA(A) receptors. The mixture of the Saaz and Saphir hop varieties may thus help mitigate sleep disturbances compared to other hop varieties.
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Suh, Hyung Joo
보건과학대학 (바이오시스템의과학부)
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