Neural-Cadherin Influences the Homing of Terminally Differentiated Memory CD8 T Cells to the Lymph Nodes and Bone Marrow
- Authors
- Kim, Kyong Hoon; Choi, Aryeong; Kim, Sang Hoon; Song, Heonju; Jin, Seohoon; Kim, Kyungim; Jang, Jaebong; Choi, Hanbyeul; Jung, Yong Woo
- Issue Date
- 11월-2021
- Publisher
- KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
- Keywords
- homeostasis; homing; memory CD8 T cells; neural cadherin
- Citation
- MOLECULES AND CELLS, v.44, no.11, pp.795 - 804
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- MOLECULES AND CELLS
- Volume
- 44
- Number
- 11
- Start Page
- 795
- End Page
- 804
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/135944
- DOI
- 10.14348/molcells.2021.0137
- ISSN
- 1016-8478
- Abstract
- Memory T (T-M) cells play an important role in the long-term defense against pathogen reinvasion. However, it is still unclear how these cells receive the crucial signals necessary for their longevity and homeostatic turnover. To understand how T-M cells receive these signals, we infected mice with lymphocytic choriomeningitis virus (LCMV) and examined the expression sites of neural cadherin (N-cadherin) by immunofluorescence microscopy. We found that N-cadherin was expressed in the surroundings of the white pulps of the spleen and medulla of lymph nodes (LNs). Moreover, T-M cells expressing high levels of killer cell lectin-like receptor G1 (KLRG1), a ligand of N-cadherin, were co-localized with N-cadherin(+) cells in the spleen but not in LNs. We then blocked N-cadherin in vivo to investigate whether it regulates the formation or function of T-M cells. The numbers of CD127(hi)CD62L(hi) T-M cells in the spleen of memory P14 chimeric mice declined when N-cadherin was blocked during the contraction phase, without functional impairment of these cells. In addition, when CD127(lo)KLRG1(hi) T-M cells were adoptively transferred into anti- N-cadherin- treated mice compared with control mice, the number of these cells was reduced in the bone marrow and LNs, with-out functional loss. Taken together, our results suggest that N-cadherin participates in the development of CD127(hi)CD62L(hi) T-M cells and homing of CD127(lo)KLRG1(hi) T-M cells to lymphoid organs.
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