Longitudinal Assessment of Antisevere Acute Respiratory Syndrome Coronavirus 2 Immune Responses for Six Months Based on the Clinical Severity of Coronavirus Disease 2019
- Authors
- Noh, Ji Yun; Kwak, Jeong-Eun; Yang, Jeong-Sun; Hwang, Soon Young; Yoon, Jin Gu; Seong, Hye; Hyun, Hakjun; Lim, Chae Seung; Yoon, Soo-Young; Ryou, Jungsang; Lee, Joo-Yeon; Kim, Sung-Soon; Park, Su-Hyung; Cheong, Hee Jin; Kim, Woo Joo; Shin, Eui-Cheol; Song, Joon Young
- Issue Date
- 1-9월-2021
- Publisher
- OXFORD UNIV PRESS INC
- Keywords
- COVID-19; SARS-CoV-2; cellular immunity; humoral immunity; longevity
- Citation
- JOURNAL OF INFECTIOUS DISEASES, v.224, no.5, pp.754 - 763
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF INFECTIOUS DISEASES
- Volume
- 224
- Number
- 5
- Start Page
- 754
- End Page
- 763
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/136405
- DOI
- 10.1093/infdis/jiab124
- ISSN
- 0022-1899
- Abstract
- Background. There is insufficient data on the longevity of immunity acquired after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods. We aimed to evaluate the duration of SARS-CoV-2-specific humoral and cellular immunity according to the clinical severity of coronavirus disease 2019 (COVID-19). The study population comprised asymptomatic (n = 14), symptomatic/ nonpneumonic (n = 42), and pneumonic (n = 41) patients. Results. The anti-SARS-CoV-2 immunoglobulin class G and neutralizing antibody (NAb) titers lasted until 6 months after diagnosis, with positivity rates of 66.7% and 86.9%, respectively. Older age, prolonged viral shedding, and accompanying pneumonia were more frequently found in patients with sustained humoral immunity. Severe acute respiratory syndrome coronavirus 2-specific T-cell response was strongly observed in pneumonic patients and prominent in individuals with sustained humoral immunity. Conclusions. In conclusion, most (>85%) patients carry NAb until 6 months after diagnosis of SARS-CoV-2 infection, providing insights for establishing vaccination strategies against COVID-19.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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