Performance evaluation of the Anysis-200 platelet function analyzer in cardiac patients
- Authors
- Park, Seong Jun; Yoon, Jung; Seo, Hong Seog; Lim, Chae Seung
- Issue Date
- 2022
- Publisher
- IOS PRESS
- Keywords
- Platelet function; Anysis-200 analyzer; PFA-200 analyzer
- Citation
- CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, v.80, no.1, pp.17 - 24
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
- Volume
- 80
- Number
- 1
- Start Page
- 17
- End Page
- 24
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/136585
- DOI
- 10.3233/CH-190801
- ISSN
- 1386-0291
- Abstract
- BACKGROUND: Platelet function analysis is crucial in assessing the hemostatic status to evaluate congenital and acquired platelet function defects. The Anysis-200 analyzer is a new automated lab-on-a-chip-based platelet function analyzer. OBJECTIVE: We aimed to evaluate a new platelet function analyzing system, the Anysis-200 in comparison to the Platelet Function Analyzer (PFA)-200 in cardiac patients. METHODS: Citrated blood was collected from 174 patients who visited the Department of Cardiology. The Anysis-200 consists of two kits, the microchips with collagen and epinephrine-coated membrane (C/EPI) or adenosine diphosphate-coated membrane (C/ADP). Platelet clogging in the Anysis-200 is measured by the blood migration distance obtained by a camera, which is compatible with the closure time in the PFA-200. We performed Anysis-200 and PFA-200 analyzers simultaneously and compared the results. RESULTS: The sensitivity and specificity of the Anysis-200 C/EPI kit in comparison to the PFA-200 C/EPI kit were 63.41% and 91.43%, respectively. Regarding the C/ADP kit, the sensitivity and specificity of the Anysis-200 were 58.97% and 74.29%, respectively. The agreement rate between the Anysis-200 and PFA-200 for C/EPI was 83.35% and 70.14% for C/ADP. CONCLUSIONS: The Anysis-200, which applies a novel method to detect platelet clogging, has shown moderate to fair agreement with the PFA-200. This test is potentially useful for screening cardiac patients with an abnormal platelet function.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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