Associations of Serum Vitamin D Level with Sarcopenia, Non-Alcoholic Fatty Liver Disease (NAFLD), and Sarcopenia in NAFLD Among People Aged 50 Years and Older: The Korea National Health and Nutrition Examination Survey IV-V
- Authors
- Hong, Jihye; Shin, Woo-Kyoung; Lee, Jung Woo; Lee, Seung-Yeon; Kim, Yookyung
- Issue Date
- 2022
- Publisher
- MARY ANN LIEBERT, INC
- Keywords
- skeletal muscle index; muscle mass; nonalcoholic steatohepatitis; serum vitamin D; aging; KNHANES
- Citation
- METABOLIC SYNDROME AND RELATED DISORDERS, v.20, no.4, pp.210 - 218
- Indexed
- SCIE
SCOPUS
- Journal Title
- METABOLIC SYNDROME AND RELATED DISORDERS
- Volume
- 20
- Number
- 4
- Start Page
- 210
- End Page
- 218
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/136628
- DOI
- 10.1089/met.2021.0106
- ISSN
- 1540-4196
- Abstract
- Background: The role of serum 25-hydroxyvitamin D [25(OH)D] levels in the development of sarcopenia in non-alcoholic fatty liver disease (NAFLD) remains controversial. We investigated the association between vitamin D levels, occurrence of sarcopenia, NAFLD, and sarcopenia in NAFLD in adults aged >50 years.Methods: This study used data pertaining to 5396 adults aged >50 years (1870 men and 3526 women) from the 2008-2011 Korea National Health and Nutrition Examination Survey. Appendicular skeletal muscle mass adjusted by weight (ASM/Wt) was used to diagnose sarcopenia, and NAFLD was diagnosed using the NAFLD fat score.Results: The lowest quintile of serum 25(OH)D level (4.85-15.26 ng/mL) was associated with an increased occurrence of sarcopenia [odds ratio (OR) 2.65; 95% confidence interval (CI) 1.64-4.27], NAFLD (OR 1.82; 95% CI 1.19-2.96), and sarcopenia in NAFLD (OR 2.25; 95% CI 1.26-4.03) in men. In women, sarcopenia (OR 1.80; 95% CI 1.29-2.51) was also significantly associated with serum vitamin D levels, whereas high levels of vitamin D were not significantly related to NAFLD.Conclusions: Serum vitamin D levels are associated with sarcopenia, NAFLD, and sarcopenia in NAFLD. Vitamin D level can be a useful marker of sarcopenia and NAFLD, especially in men.
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Collections - College of Education > Department of Home Economics Education > 1. Journal Articles
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