Establishment of an Experimental System for Intraperitoneal Chemotherapy in a Rat Model
- Authors
- Park, Sunwoo; Park, Soo Jin; Lee, Hee Su; Ham, Jiyeon; Lee, Eun Ji; Kim, Junsik; Ryu, Soomin; Seol, Aeran; Lim, Whasun; Lee, Jung Chan; Song, Gwonhwa; Kim, Hee seung
- Issue Date
- Sep-2021
- Publisher
- INT INST ANTICANCER RESEARCH
- Keywords
- Experimental system; intraperitoneal chemotherapy; rat
- Citation
- IN VIVO, v.35, no.5, pp.2703 - 2710
- Indexed
- SCIE
SCOPUS
- Journal Title
- IN VIVO
- Volume
- 35
- Number
- 5
- Start Page
- 2703
- End Page
- 2710
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/136738
- DOI
- 10.21873/invivo.12554
- ISSN
- 0258-851X
- Abstract
- Aim: To establish an experimental system for comparing different methods of intraperitoneal chemotherapy in a rat model. Materials and Methods: We used six-week-old Sprague-Dawley rats, and created an early postoperative intraperitoneal chemotherapy (EPIC) system using 18-gauge syringes and evacuators, and a hyperthermic intraperitoneal chemotherapy (HIPEC) system using two peristaltic pumps which controlled the flow rate and temperature. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) was achieved using a nozzle for dispersing aerosols at a flow rate up to 41.5 ml/min. The distribution and intensity of 0.2% trypan blue dye was compared among three methods. Results: The distribution was limited and the intensity was weak after EPIC, and the dye stained moderately in gravity-dependent regions after HIPEC. On the other hand, the distribution was the most comprehensive, and the intensity was the greatest after PIPAC. Conclusion: This experimental system in a rat model may reflect the comparative effect among EPIC, HIPEC and PIPAC in humans.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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