Efficacy of Triptorelin 3-Month Depot Compared to 1-Month Depot for the Treatment of Korean Girls with Central Precocious Puberty in Single Tertiary Center
- Authors
- Chung, Lindsey Yoojin; Kang, Eungu; Nam, Hyo-Kyoung; Rhie, Young-Jun; Lee, Kee-Hyoung
- Issue Date
- 30-8월-2021
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Central Precocious Puberty; Gonadotropin-releasing Hormone Analogue; Korea; Triptorelin Pamoate
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.36, no.34, pp.1 - 9
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 36
- Number
- 34
- Start Page
- 1
- End Page
- 9
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/136797
- DOI
- 10.3346/jkms.2021.36.e219
- ISSN
- 1011-8934
- Abstract
- Background: Triptorelin depot is largely used to treat central precocious puberty (CPP) in children, and a 3-month depot has been introduced. However, data about the 3-month gonadotropin-releasing hormone use for treatment of CPP in Korean girls are not available. This study was conducted to compare the efficacy of a triptorelin 11.25 mg 3-month depot with that of a 3.75 mg 1-month depot in suppressing pubertal development for the treatment of CPP. Methods: A retrospective study, including 106 girls with CPP treated with triptorelin, was conducted. Fifty patients were treated with a triptorelin 3-month depot, and 56 were treated with a triptorelin 1-month depot. Serum luteinizing hormone (LH), follicle-stimulating hormone, and estradiol levels were analysed every 6 months after the visit. The height and bone age of each patient was evaluated at the beginning of treatment, after 6 months, and one year after therapy. Results: The baseline characteristics of the girls treated with a 3-month depot were similar to those of the girls treated with a 1-month depot. A suppressed levels of LH to the triptorelin injection (serum LH < 2.5 IU/L) at 6 months was seen in 90.0% and 98.2% of the girls treated with the 3-month and 1-month depots, respectively (P = 0.160). After 1 year of treatment, a suppressed levels of LH was seen in 93.5% and 100% of the girls treated with the 3-month and 1-month depots, respectively (P = 0.226). Height velocity showed no significant difference between the two groups. Degree of bone age advancement decreased from 1.22 +/- 0.07 and 1.22 +/- 0.08 years at baseline (P = 0.914) to 1.16 +/- 0.07 and 1.17 +/- 0.08 in the girls treated with the 3-month and 1-month depots after 1 year, respectively (P = 0.481). Conclusion: This study showed that the efficacy of long-acting triptorelin 3-month was comparable to 1-month depot regarding hormonal suppression and inhibition of bone maturation. The triptorelin 11.25 mg 3-month depot is an effective treatment for girls with CPP.
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