miR-181a-regulated pathways in T-cell differentiation and aging
- Authors
- Kim, Chulwoo; Ye, Zhongde; Weyand, Cornelia M.; Goronzy, Jorg J.
- Issue Date
- 15-6월-2021
- Publisher
- BMC
- Keywords
- Infectious disease; Memory T cells; Replication stress; T cell activation; T cell aging; T cell differentiation; Vaccine; miR-181a; microRNA
- Citation
- IMMUNITY & AGEING, v.18, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- IMMUNITY & AGEING
- Volume
- 18
- Number
- 1
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/137301
- DOI
- 10.1186/s12979-021-00240-1
- ISSN
- 1742-4933
- Abstract
- MicroRNAs (miRNAs) are regulatory noncoding RNAs important for many aspects of cellular processes including cell differentiation and proliferation. Functions of numerous miRNAs have been identified in T cells, with miR-181a regulating T cell activation thresholds during thymic T cell development and during activation of peripheral T cells. Intriguingly, miR-181a is implicated in defective antiviral and vaccine responses in older individuals, as its expression declines in naive T cells with increasing age. Here, we review the pathways that are regulated by miR-181a and that explain the unique role of miR-181a in T cell development, T cell activation and antiviral T cell responses. These studies provide a framework for understanding how a decline in miR-181a expression in T cells could contribute to age-related defects in adaptive immunity. We furthermore review the mechanisms that cause the age-related decline in miR-181a expression and discuss the potential of restoring miR-181a expression or targeting miR-181a-regulated pathways to improve impaired T cell responses in older individuals.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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