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Effect of Human or Mouse IL-7 on the Homeostasis of Porcine T LymphocytesEffect of Human or Mouse IL-7 on the Homeostasis of Porcine T Lymphocytes
- Other Titles
- Effect of Human or Mouse IL-7 on the Homeostasis of Porcine T Lymphocytes
- Authors
- Hong, Ji Hwa; Kim, Sang Hoon; Kim, Hyun Gyung; Jang, Jun Ho; Son, Ryeo Gang; Pack, Seung Pil; Park, Young-Ho; Kang, Philyong; Jeong, Kang-Jin; Kim, Ji-Su; Choi, Hanbyeul; Kim, Sun-Uk; Jung, Yong Woo
- Issue Date
- 6월-2021
- Publisher
- KOREA ASSOC IMMUNOLOGISTS
- Keywords
- Graft-versus-host disease; IL-7; Miniature swine; T-lymphocytes
- Citation
- IMMUNE NETWORK, v.21, no.3, pp.1 - 13
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- IMMUNE NETWORK
- Volume
- 21
- Number
- 3
- Start Page
- 1
- End Page
- 13
- ISSN
- 1598-2629
- Abstract
- Due to the inconsistent fluctuation of blood supply for transfusion, much attention has been paid to the development of artificial blood using other animals. Although mini-pigs are candidate animals, contamination of mini-pig T cells in artificial blood may cause a major safety concern. Therefore, it is important to analyze the cross-reactivity of IL-7, the major survival factor for T lymphocytes, between human, mouse, and mini-pig. Thus, we compared the protein sequences of IL-7 and found that porcine IL-7 was evolutionarily different from human IL-7. We also observed that when porcine T cells were cultured with either human or mouse IL-7, these cells did not increase the survival or proliferation compared to negative controls. These results suggest that porcine T cells do not recognize human or mouse IL-7 as their survival factor.
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Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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