Targeted therapy response in early versus late recurrence of renal cell carcinoma after surgical treatment: A propensity score-matched study using the Korean Renal Cancer Study Group database
- Authors
- Lee, Chan Ho; Chung, Jinsoo; Kwak, Cheol; Jeong, Chang Wook; Seo, Seong Il; Kang, Minyong; Hong, Sung-Hoo; Song, Cheryn; Park, Jae Young; Hwang, Eu Chang; Lee, Hakmin; Ku, Ja Yoon; Seo, Won Ik; Choi, Seock Hwan; Ha, Hong Koo
- Issue Date
- 4월-2021
- Publisher
- WILEY
- Keywords
- late recurrence; prognosis; renal cell carcinoma; targeted therapy
- Citation
- INTERNATIONAL JOURNAL OF UROLOGY, v.28, no.4, pp.417 - 423
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF UROLOGY
- Volume
- 28
- Number
- 4
- Start Page
- 417
- End Page
- 423
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/137671
- DOI
- 10.1111/iju.14485
- ISSN
- 0919-8172
- Abstract
- Objectives: To investigate the clinicopathological features and outcomes of targeted therapy in patients with recurrence of renal cell carcinoma in < 5 years or >= 5 years after the surgical treatment for renal cell carcinoma. Methods: Patients with metastatic renal cell carcinoma treated with targeted therapy in a multicenter database were retrospectively characterized according to time from surgery to recurrence. Early recurrence was defined as recurrence within 5 years after surgery, and late recurrence was defined as occurring >= 5 years after surgery. The propensity scores for recurrence status were calculated, and patients with late recurrence were matched to patients with early recurrence at a 1:3 ratio. The oncological outcomes of targeted therapy in both groups were compared. Results: Among 716 patients, 512 (71.5%) experienced early recurrence and 204 (28.5%) experienced late recurrence. The patients with late recurrence presented with younger age at surgery, lower tumor stages and Fuhrman grade, and fewer sarcomatoid features and lymphovascular invasion (all P < 0.005). All differences in clinicopathological characteristics before targeted therapy disappeared after matching. Patients with late recurrence had significantly longer median overall survival (56 months vs 36 months; P < 0.0001) and median first-line progression-free survival (12 months vs 8 months; P = 0.031). The early recurrence status was a significantly worse predictor for overall survival and first-line progression-free survival (hazard ratio 1.30, P = 0.007; and hazard ratio 1.76, P < 0.001, respectively). Conclusions: Late recurrence might have prognostic value in terms of oncological outcomes in metastatic renal cell carcinoma treated with targeted therapy.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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