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In Vitro Prebiotic and Anti-Colon Cancer Activities of Agar-Derived Sugars from Red Seaweeds

Authors
Yun, Eun JuYu, SoraKim, Young-AhLiu, Jing-JingKang, NamJin, Yong-SuKim, Kyoung
Issue Date
4월-2021
Publisher
MDPI
Keywords
red seaweeds; agarose; agarotriose; 3; 6-anhydro-l-galactose; prebiotics; anti-colon cancer activity
Citation
MARINE DRUGS, v.19, no.4
Indexed
SCIE
SCOPUS
Journal Title
MARINE DRUGS
Volume
19
Number
4
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/137694
DOI
10.3390/md19040213
ISSN
1660-3397
Abstract
Numerous health benefits of diets containing red seaweeds or agar-derived sugar mixtures produced by enzymatic or acid hydrolysis of agar have been reported. However, among various agar-derived sugars, the key components that confer health-beneficial effects, such as prebiotic and anti-colon cancer activities, remain unclear. Here, we prepared various agar-derived sugars by multiple enzymatic reactions using an endo-type and an exo-type of beta-agarase and a neoagarobiose hydrolase and tested their in vitro prebiotic and anti-colon cancer activities. Among various agar-derived sugars, agarotriose exhibited prebiotic activity that was verified based on the fermentability of agarotriose by probiotic bifidobacteria. Furthermore, we demonstrated the anti-colon cancer activity of 3,6-anhydro-l-galactose, which significantly inhibited the proliferation of human colon cancer cells and induced their apoptosis. Our results provide crucial information regarding the key compounds derived from red seaweeds that confer beneficial health effects, including prebiotic and anti-colon cancer activities, to the host.
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