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Targeting cancer’s sweet spot: UGP2 as a therapeutic vulnerability
- Issue Date
- 2021
- Publisher
- Taylor and Francis Ltd.
- Keywords
- UDP-glucose; UGP2; YAP; cancer metabolism; glycosylation
- Citation
- Molecular and Cellular Oncology, v.8, no.6
- Indexed
- SCOPUS
- Journal Title
- Molecular and Cellular Oncology
- Volume
- 8
- Number
- 6
- ISSN
- 2372-3556
- Abstract
- Understanding the mechanisms governing metabolic reprogramming that underlie potential vulnerabilities in cancer cells is key to developing novel therapeutic strategies. The catalytic enzyme UDP-glucose pyrophosphorylase 2 (UGP2) drives the production of UDP-glucose. Our recent work demonstrated the crucial role of UGP2 in cancer growth and its regulation of cellular metabolic processes. © 2021 Taylor & Francis Group, LLC.
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