Differences between Staphylococcus aureus nasal carriage and IgE-sensitization to Staphylococcus aureus enterotoxin on risk factors and effects in adult population
- Authors
- Park, Han-Ki; Yoo, Seok-Ju; Kim, Taek Soo; Kim, Byung-Keun; Jang, Sekyung; Kim, Sung Yeon; Lee, Kwan
- Issue Date
- 31-1월-2022
- Publisher
- BMC
- Keywords
- Staphylococcus aureus; Staphylococcal enterotoxins; Risk factors; Immunoglobulin E; Eosinophil; Cough; Sputum
- Citation
- ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, v.18, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
- Volume
- 18
- Number
- 1
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/138931
- DOI
- 10.1186/s13223-022-00648-4
- ISSN
- 1710-1484
- Abstract
- Background Staphylococcus aureus (SA) nasal carriage (SA carriage) and IgE-sensitization to SA enterotoxin (SE IgE-sensitization) are known to be associated with chronic airway disease. Objective This study aimed to evaluate the differences in risk factors, type 2 inflammation and respiratory symptoms between SA carriage and SE IgE-sensitization. Methods We conducted a cross-sectional study of a community-based adult population to evaluate the environmental exposure and health impact of the Pohang Industrial Complex, Korea. Participants were examined based on self-reported questionnaires, nasal swab, and blood sampling. Results There were 307 participants, and the overall prevalence of SA carriage and SE IgE-sensitization was 26.1% (80/307) and 25.7% (79/307), respectively. An urban environment was significantly correlated with SA carriage, whereas age and obesity were significantly correlated with SE IgE-sensitization. SA carriage was not associated with an increase in total IgE and blood eosinophil count, whereas SE IgE-sensitization was associated with an increased total IgE and blood eosinophil count. SA carriage was significantly correlated with cough persisting for more than three weeks (OR, 3.044; 95% CI, 1.137-8.153) and sputum (OR, 2.429; 95% CI, 1.008-5.854). SE IgE-sensitization was a significant correlation with only sputum (OR, 2.452; 95% CI, 1.066-5.640). SA carriage and SE IgE-sensitization showed a synergistic effect on the prevalence of cough and sputum. Conclusion SA carriage was associated with the urban environment, and SE IgE-sensitization was associated with the elderly and obesity. SA carriage and SE IgE-sensitization had different correlation with type 2 inflammation and airway symptoms.
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