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Photoprotective effects of sphingomyelin-containing milk phospholipids in ultraviolet B-irradiated hairless mice by suppressing nuclear factor-kappa B expression

Authors
Ahn, YejinKim, Min G.Choi, Yong J.Lee, Sang J.Suh, Hyung J.Jo, Kyungae
Issue Date
3월-2022
Publisher
ELSEVIER SCIENCE INC
Keywords
milk phospholipid; photoprotective activity; nuclear factor-kappa B (NF-kappa B); ultraviolet B irradiation
Citation
JOURNAL OF DAIRY SCIENCE, v.105, no.3, pp.1929 - 1939
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF DAIRY SCIENCE
Volume
105
Number
3
Start Page
1929
End Page
1939
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/139357
DOI
10.3168/jds.2021-21192
ISSN
0022-0302
Abstract
Ceramide-containing phospholipids improve skin hydration and barrier function and are ideal for use in skin care products. In this study, we evaluated the photoprotective effect of milk phospholipids on the skin condition of UVB-irradiated hairless mice. Skin parameters were assessed following oral administration of milk phospholipids. The UVB irradiation induced photoaging in mice. The animals were divided into 5 groups: a control group (oral administration of saline with no UBV irradiation), UVB group (oral administration of saline with UVB irradiation), and 3 UVB irradiation groups receiving the milk phospholipids at 3 different concentrations of oral administration, 50 mg/kg (ML group), 100 mg/kg (MM group), and 150 mg/kg (MH group), for 8 wk. An increase in skin hydration and transepidermal water loss were improved in the 150 mg/kg of milk phospholipid-administered group. Hematoxylin and eosin staining revealed a decrease in epidermal thickness in the milk phospholipid-administered groups (50, 100, and 150 mg/kg of body weight). In particular, the 100 and 150 mg/kg groups showed significant changes in the area, length, and depth of the wrinkles compared with the UVB group. Moreover, the gene expression of matrix metalloproteins was attenuated, and that of proinflammatory cytokines, especially tumor necrosis factor-alpha, was significantly reduced in the milk phospholipid-administered groups than in the UVB group. The reduced ceramide and increased sphingosine-1-phosphate levels in the skin tissue due to UVB exposure were restored to levels similar to those of the control group following milk phospholipid administration. These results were confirmed to be due to the downregulation of protein expression of nuclear factor kappa-B (NF-kappa B) and phosphorylated I kappa B-alpha (inhibitor of kappa B alpha). Collectively, oral administration of milk phospholipids improves skin health through a synergistic effect on photoprotective activity.
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Suh, Hyung Joo
보건과학대학 (바이오시스템의과학부)
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