Fluorescence Turn-on Synthetic Lipid Rafts on Supramolecular Sheets and Hierarchical Concanavalin A Assembly
- Authors
- 김용주
- Issue Date
- 4월-2019
- Publisher
- JOHN WILEY AND SONS LTDSOUTHERN GATECHICHESTER, WEST SUSSEXPO19 8SQVGORAYSKA@WILEY.COM
- Citation
- CHEMISTRY - AN ASIAN JOURNAL, v.14, no.7, pp.952 - 957
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMISTRY - AN ASIAN JOURNAL
- Volume
- 14
- Number
- 7
- Start Page
- 952
- End Page
- 957
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/139686
- DOI
- 10.1002/asia.201900122
- ISSN
- 1861-4728
- Abstract
- Here we report fluorescence turn-on synthetic lipid rafts by self-assembly of a cationic distyrylanthracene derivative on a negatively-charged sheet in an aqueous solution. First, the negatively-charged 2D membrane structure is formed by lateral associations of aromatic rods with carboxylate groups. Then, the synthetic rafts are floated on the surface of the negatively-charged sheets through electrostatic interactions. The fluorescence of the synthetic rafts is turned on due to the aggregation of the positively-charged AIE dye on the sheets, facilitating monitoring of the formation of rafts. Concanavalin A (Con A) protein can load hierarchically onto the synthetic rafts at neutral pH to provide discrete Con A aggregates with a uniform size of ≈12 nm. The uniform aggregates of Con A on the synthetic rafts can stimulate Jurkat cells with enhanced efficiency, as compared with random-sized aggregates of Con A.
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