Integrative functional genomic analysis of human brain development and neuropsychiatric risks
- Authors
- 안준용
- Issue Date
- Dec-2018
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Citation
- SCIENCE, v.362, no.6420, pp.1264 - 1264
- Indexed
- SCIE
SCOPUS
- Journal Title
- SCIENCE
- Volume
- 362
- Number
- 6420
- Start Page
- 1264
- End Page
- 1264
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/139707
- ISSN
- 0036-8075
- Abstract
- To broaden our understanding of human neurodevelopment, we profiled transcriptomic and epigenomic landscapes across brain regions and/or cell types for the entire span of prenatal and postnatal development. Integrative analysis revealed temporal, regional, sex, and cell type-specific dynamics. We observed a global transcriptomic cup-shaped pattern, characterized by a late fetal transition associated with sharply decreased regional differences and changes in cellular composition and maturation, followed by a reversal in childhood-adolescence, and accompanied by epigenomic reorganizations. Analysis of gene coexpression modules revealed relationships with epigenomic regulation and neurodevelopmental processes. Genes with genetic associations to brain-based traits and neuropsychiatric disorders (including MEF2C, SATB2, SOX5, TCF4, and TSHZ3) converged in a small number of modules and distinct cell types, revealing insights into neurodevelopment and the genomic basis of neuropsychiatric risks.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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