Genetic heterogeneity in autism: From single gene to a pathway perspective
- Authors
- 안준용
- Issue Date
- Sep-2016
- Publisher
- ELSEVIER LTD
- Citation
- NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v.68, pp.442 - 453
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Volume
- 68
- Start Page
- 442
- End Page
- 453
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/139867
- ISSN
- 0149-7634
- Abstract
- The extreme genetic heterogeneity of autism spectrum disorder (ASD) represents a major challenge. Recent advances in genetic screening and systems biology approaches have extended our knowledge of the genetic etiology of ASD. In this review, we discuss the paradigm shift from a single gene causation model to pathway perturbation model as a guide to better understand the pathophysiology of ASD. We discuss recent genetic findings obtained through next-generation sequencing (NGS) and examine various integrative analyses using systems biology and complex networks approaches that identify convergent patterns of genetic elements associated with ASD.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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