Submillisecond organic synthesis: Outpacing Fries rearrangement through microfluidic rapid mixing
- Authors
- 김희진
- Issue Date
- 5월-2016
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Citation
- SCIENCE, v.352, no.6286, pp.691 - 694
- Indexed
- SCIE
SCOPUS
- Journal Title
- SCIENCE
- Volume
- 352
- Number
- 6286
- Start Page
- 691
- End Page
- 694
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/139876
- DOI
- 10.1126/science.aaf1389
- ISSN
- 0036-8075
- Abstract
- In chemical synthesis, rapid intramolecular rearrangements often foil attempts at site-selective bimolecular functionalization. We developed a microfluidic technique that outpaces the very rapid anionic Fries rearrangement to chemoselectively functionalize iodophenyl carbamates at the ortho position. Central to the technique is a chip microreactor of our design, which can deliver a reaction time in the submillisecond range even at cryogenic temperatures. The microreactor was applied to the synthesis of afesal, a bioactive molecule exhibiting anthelmintic activity, to demonstrate its potential for practical synthesis and production.
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Collections - College of Science > Department of Chemistry > 1. Journal Articles
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