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Heteroaromatic Moieties in the Sphingosine Backbone of alpha-Galactosylceramides for Noncovalent Interactions with CD1d
- Authors
- 김용주
- Issue Date
- 2월-2012
- Publisher
- AMER CHEMICAL SOC
- Keywords
- CD1d; alpha-Galactosylceramide; cytokine secretion; noncovalent interaction; selectivity
- Citation
- ACS MEDICINAL CHEMISTRY LETTERS, v.3, no.2, pp.151 - 154
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS MEDICINAL CHEMISTRY LETTERS
- Volume
- 3
- Number
- 2
- Start Page
- 151
- End Page
- 154
- ISSN
- 19485875
- Abstract
- A series of alpha-GalCer analogues containing heterocyclic and aromatic moieties in the sphingosine backbone were synthesized to improve the selectivity in the Th1/Th2 cytokine profile via noncovalent interaction with three aromatic residues at the binding pocket of CD1d. In vitro and in vivo biological evaluations revealed the treatment of alpha-GalCer analogue (6) induced the selective stimulation of natural killer T cells to facilitate the secretion of Th2 cytokines.
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