Yeast hydrolysate ameliorates dexamethasone-induced muscle atrophy by suppressing MuRF-1 expression in C2C12 cells and C57BL/6 mice
DC Field | Value | Language |
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dc.contributor.author | Ahn, Yejin | - |
dc.contributor.author | Jo, Kyungae | - |
dc.contributor.author | Chang, Yeok Boo | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.accessioned | 2022-04-18T09:42:19Z | - |
dc.date.available | 2022-04-18T09:42:19Z | - |
dc.date.created | 2022-04-18 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/140283 | - |
dc.description.abstract | In this study, we evaluated the effects of yeast (Saccharomyces cerevisiae) hydrolysate (YH) on muscle differen-tiation and muscle atrophy inhibitory activity in C2C12 cells and atrophy inhibitory activity in a dexamethasone (DEX)-induced muscle atrophy mouse model. Jenner-Giemsa staining revealed that the length and area of myotubes increased in the YH groups. Moreover, the gene expression of myogenic differentiation 1 and myo-genin was significantly increased in the YH groups. In the DEX-induced muscle atrophy C2C12 model, the expression of muscle ring-finger protein-1 (MuRF-1), forkhead box class O3a, and Atrogin-1 were significantly reduced in the YH groups. Furthermore, in the muscle-atrophy mice model, grip strength and lean mass were increased by 1.28-fold and 3.5%, respectively compared to the control in the YH group (300 mg/kg). These results were confirmed by the downregulation of MuRF-1 in muscle. In conclusion, YH promoted muscle cell differentiation and exhibited an inhibitory effect on DEX-induced muscle atrophy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | CHAIN AMINO-ACIDS | - |
dc.subject | SKELETAL-MUSCLE | - |
dc.subject | PROTEIN-DEGRADATION | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | LEUCINE | - |
dc.subject | RATS | - |
dc.subject | MECHANISMS | - |
dc.subject | MYOGENESIS | - |
dc.title | Yeast hydrolysate ameliorates dexamethasone-induced muscle atrophy by suppressing MuRF-1 expression in C2C12 cells and C57BL/6 mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1016/j.jff.2022.104985 | - |
dc.identifier.scopusid | 2-s2.0-85123982401 | - |
dc.identifier.wosid | 000772086300002 | - |
dc.identifier.bibliographicCitation | JOURNAL OF FUNCTIONAL FOODS, v.90 | - |
dc.relation.isPartOf | JOURNAL OF FUNCTIONAL FOODS | - |
dc.citation.title | JOURNAL OF FUNCTIONAL FOODS | - |
dc.citation.volume | 90 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | CHAIN AMINO-ACIDS | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | PROTEIN-DEGRADATION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | LEUCINE | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | MYOGENESIS | - |
dc.subject.keywordAuthor | Saccharomyces cerevisiae | - |
dc.subject.keywordAuthor | Yeast hydrolysate | - |
dc.subject.keywordAuthor | Muscle atrophy | - |
dc.subject.keywordAuthor | Muscle differentiation | - |
dc.subject.keywordAuthor | Dexamethasone | - |
dc.subject.keywordAuthor | Sarcopenia | - |
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