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Yeast hydrolysate ameliorates dexamethasone-induced muscle atrophy by suppressing MuRF-1 expression in C2C12 cells and C57BL/6 mice

Authors
Ahn, YejinJo, KyungaeChang, Yeok BooSuh, Hyung Joo
Issue Date
3월-2022
Publisher
ELSEVIER
Keywords
Saccharomyces cerevisiae; Yeast hydrolysate; Muscle atrophy; Muscle differentiation; Dexamethasone; Sarcopenia
Citation
JOURNAL OF FUNCTIONAL FOODS, v.90
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF FUNCTIONAL FOODS
Volume
90
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/140283
DOI
10.1016/j.jff.2022.104985
ISSN
1756-4646
Abstract
In this study, we evaluated the effects of yeast (Saccharomyces cerevisiae) hydrolysate (YH) on muscle differen-tiation and muscle atrophy inhibitory activity in C2C12 cells and atrophy inhibitory activity in a dexamethasone (DEX)-induced muscle atrophy mouse model. Jenner-Giemsa staining revealed that the length and area of myotubes increased in the YH groups. Moreover, the gene expression of myogenic differentiation 1 and myo-genin was significantly increased in the YH groups. In the DEX-induced muscle atrophy C2C12 model, the expression of muscle ring-finger protein-1 (MuRF-1), forkhead box class O3a, and Atrogin-1 were significantly reduced in the YH groups. Furthermore, in the muscle-atrophy mice model, grip strength and lean mass were increased by 1.28-fold and 3.5%, respectively compared to the control in the YH group (300 mg/kg). These results were confirmed by the downregulation of MuRF-1 in muscle. In conclusion, YH promoted muscle cell differentiation and exhibited an inhibitory effect on DEX-induced muscle atrophy.
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Suh, Hyung Joo
보건과학대학 (바이오시스템의과학부)
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