2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapyopen access
- Authors
- Xu, Yunjie; Wang, Yingwei; An, Jusung; Sedgwick, Adam C.; Li, Mingle; Xie, Jianlei; Hu, Weibin; Kang, Jianlong; Sen, Sajal; Steinbrueck, Axel; Zhang, Bin; Qiao, Lijun; Wageh, Swelm; Arambula, Jonathan F.; Liu, Liping; Zhang, Han; Sessler, Jonathan L.; Kim, Jong Seung
- Issue Date
- 8월-2022
- Publisher
- KEAI PUBLISHING LTD
- Keywords
- 2D MXene; Nanomedi cine; Prodrug; Iron chelation; Photothermal therapy
- Citation
- BIOACTIVE MATERIALS, v.14, pp.76 - 85
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOACTIVE MATERIALS
- Volume
- 14
- Start Page
- 76
- End Page
- 85
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/141075
- DOI
- 10.1016/j.bioactmat.2021.12.011
- ISSN
- 2452-199X
- Abstract
- An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation, tumor progression and metastasis. This makes iron metabolism an attractive therapeutic target. Unfortunately, current iron-based therapeutic strategies often lack effectiveness and can elicit off-target toxicities. We report here a dual-therapeutic prodrug, DOXjade, that allows for iron chelation chemo-photothermal cancer therapy. This prodrug takes advantage of the clinically approved iron chelator deferasirox (ExJade (R)) and the topoisomerase 2 inhibitor, doxorubicin (DOX). Loading DOXjade onto ultrathin 2D Ti3C2 MXene nanosheets produces a construct, Ti3C2-PVP@DOXjade, that allows the iron chelation and chemotherapeutic functions of DOXjade to be photo-activated at the tumor sites, while potentiating a robust photothermal effect with photothermal conversion efficiencies of up to 40%. Antitumor mechanistic investigations reveal that upon activation, Ti3C2-PVP@DOXjade serves to promote apoptotic cell death and downregulate the iron depletion-induced iron transferrin receptor (TfR). A tumor pH-responsive iron chelation/photothermal/chemotherapy antitumor effect was achieved both in vitro and in vivo. The results of this study highlight what may constitute a promising iron chelation-based phototherapeutic approach to cancer therapy.
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Collections - College of Science > Department of Chemistry > 1. Journal Articles
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