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The discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against Mycobacterium tuberculosisopen access
- Issue Date
- 22-Jun-2022
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- RSC ADVANCES, v.12, no.29, pp.18884 - 18888
- Indexed
- SCIE
SCOPUS
- Journal Title
- RSC ADVANCES
- Volume
- 12
- Number
- 29
- Start Page
- 18884
- End Page
- 18888
- ISSN
- 2046-2069
- Abstract
- The formylglycine-generating enzyme is a key regulator that converts sulfatase into an active form. Despite its key role in many diseases, enzyme activity inhibitors have not yet been reported. In this study, we investigated penta-peptide ligands for FGE activity inhibition and discovered two hit peptides. In addition, the lead peptides also showed potential antibacterial effects in a Mycobacterium tuberculosis model.
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Related Researcher
- Lee, Jun Seok
- College of Medicine (Department of Medical Science)