A prospective multi-centre study of susceptibility map-weighted MRI for the diagnosis of neurodegenerative parkinsonism
- Authors
- Sung, Young Hee; Kim, Joong-Seok; Yoo, Sang-Won; Shin, Na-Young; Nam, Yoonho; Ahn, Tae-Beom; Yoo, Dallah; Lee, Kyung Mi; Kim, Hyug-Gi; Koh, Seong-Beom; Kim, Jinhee; Kim, Ilsoo; Kwon, Do-Young; Lee, Younghen; Kim, Chulhan; Chung, Sun Ju; Jo, Sungyang; Lee, Seung Hyun; Kim, Sang Joon; Kim, Minjae; Lyoo, Chul Hyoung; Baek, Min Seok; Kang, Suk Yun; Chang, Suk Ki; Jo, Sang-Won; Lee, Seun Ah; Ma, Hyeo-il; Kim, Young Eun; Kim, Eun Soo; Kim, Yun Joong; Kim, Hyun Sook; Woo, Min-Hee; Choi, Hye Jeong; Kim, Eung Yeop
- Issue Date
- 5월-2022
- Publisher
- SPRINGER
- Keywords
- Parkinson disease; Substantia nigra; Magnetic resonance imaging
- Citation
- EUROPEAN RADIOLOGY, v.32, no.5, pp.3597 - 3608
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN RADIOLOGY
- Volume
- 32
- Number
- 5
- Start Page
- 3597
- End Page
- 3608
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/143227
- DOI
- 10.1007/s00330-021-08454-z
- ISSN
- 0938-7994
- Abstract
- Objectives This study aimed to compare susceptibility map-weighted imaging (SMwI) using various MRI machines (three vendors) with N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophe nyl)nortropane (F-18-FP-CIT) PET in the diagnosis of neurodegenerative parkinsonism in a multi-centre setting. Methods We prospectively recruited 257 subjects, including 157 patients with neurodegenerative parkinsonism, 54 patients with non-neurodegenerative parkinsonism, and 46 healthy subjects from 10 hospitals between November 2019 and October 2020. All participants underwent both SMwI and F-18-FP-CIT PET. SMwI was interpreted by two independent reviewers for the presence or absence of abnormalities in nigrosome 1, and discrepancies were resolved by consensus. F-18-FP-CIT PET was used as the reference standard. Inter-observer agreement was tested using Cohen's kappa coefficient. McNemar's test was used to test the agreement between the interpretations of SMwI and F-18-FP-CIT PET per participant and substantia nigra (SN). Results The inter-observer agreement was 0.924 and 0.942 per SN and participant, respectively. The diagnostic sensitivity of SMwI was 97.9% and 99.4% per SN and participant, respectively; its specificity was 95.9% and 95.2%, respectively, and its accuracy was 97.1% and 97.7%, respectively. There was no significant difference between the results of SMwI and F-18-FP-CIT PET (p > 0.05, for both SN and participant). Conclusions This study demonstrated that the high diagnostic performance of SMwI was maintained in a multi-centre setting with various MRI scanners, suggesting the generalisability of SMwI for determining nigrostriatal degeneration in patients with parkinsonism.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.