Effect of hop mixture containing xanthohumol on sleep enhancement in a mouse model and ROS scavenging effect in oxidative stress-induced HT22 cells
DC Field | Value | Language |
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dc.contributor.author | MIN, Byungjick | - |
dc.contributor.author | PARK, Chun Woong | - |
dc.contributor.author | AHN, Yeljin | - |
dc.contributor.author | HONG, Ki-Bae | - |
dc.contributor.author | CHO, Hyeok-Jun | - |
dc.contributor.author | LEE, Jang Hyun | - |
dc.contributor.author | JO, Kyungae | - |
dc.contributor.author | SUH, Hyung Joo | - |
dc.date.accessioned | 2022-08-15T09:40:45Z | - |
dc.date.available | 2022-08-15T09:40:45Z | - |
dc.date.created | 2022-08-12 | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 0101-2061 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/143256 | - |
dc.description.abstract | Hops (Humulus lupulus L. [Cannabaceae]), used to increase storage and palatability of food, exert various pharmacological effects, including sleep-promoting and antioxidant effects. Here, we evaluated the effects of Saaz, Saphir, Simcoe, and their mixtures on pentobarbital-induced sleep in mice and reactive oxygen species (ROS) production in H2O2-treated HT22 cells. Compared to administration of Saaz, Simcoe, and Saphir alone, the administration of Saaz/Saphir (75:25) and Simcoe/Saphir (50:50) mixtures resulted in slightly longer sleep durations in pentobarbital-administered mice. The Saaz/Saphir (75:25) group showed a longer sleep duration in the caffeine-induced insomnia model and slightly lower IC50 values for radicals than the Simcoe/Saphir (50:50) group. Xanthohumol present in hop mixtures suppressed ROS production and increased the expression of superoxide dismutase-1, catalase, and glutathione peroxidase-1 in H2O2-treated HT22 cells. Collectively, Simcoe/Saphir (50:50) and Saaz/Saphir (75:25) mixtures were more effective in removing ROS in brain cells and promoting sleep than hops alone. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SOC BRASILEIRA CIENCIA TECNOLOGIA ALIMENTOS | - |
dc.subject | HUMULUS-LUPULUS L. | - |
dc.subject | CAPACITY | - |
dc.subject | INSOMNIA | - |
dc.subject | DAMAGE | - |
dc.subject | ACIDS | - |
dc.title | Effect of hop mixture containing xanthohumol on sleep enhancement in a mouse model and ROS scavenging effect in oxidative stress-induced HT22 cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | SUH, Hyung Joo | - |
dc.identifier.doi | 10.1590/fst.29922 | - |
dc.identifier.scopusid | 2-s2.0-85131163491 | - |
dc.identifier.wosid | 000806748200007 | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE AND TECHNOLOGY, v.42 | - |
dc.relation.isPartOf | FOOD SCIENCE AND TECHNOLOGY | - |
dc.citation.title | FOOD SCIENCE AND TECHNOLOGY | - |
dc.citation.volume | 42 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | HUMULUS-LUPULUS L. | - |
dc.subject.keywordPlus | CAPACITY | - |
dc.subject.keywordPlus | INSOMNIA | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | ACIDS | - |
dc.subject.keywordAuthor | hop mixture | - |
dc.subject.keywordAuthor | sleep | - |
dc.subject.keywordAuthor | ROS | - |
dc.subject.keywordAuthor | HT22 cell | - |
dc.subject.keywordAuthor | mouse | - |
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