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Effect of hop mixture containing xanthohumol on sleep enhancement in a mouse model and ROS scavenging effect in oxidative stress-induced HT22 cellsopen access

Authors
MIN, ByungjickPARK, Chun WoongAHN, YeljinHONG, Ki-BaeCHO, Hyeok-JunLEE, Jang HyunJO, KyungaeSUH, Hyung Joo
Issue Date
2022
Publisher
SOC BRASILEIRA CIENCIA TECNOLOGIA ALIMENTOS
Keywords
hop mixture; sleep; ROS; HT22 cell; mouse
Citation
FOOD SCIENCE AND TECHNOLOGY, v.42
Indexed
SCIE
SCOPUS
Journal Title
FOOD SCIENCE AND TECHNOLOGY
Volume
42
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/143256
DOI
10.1590/fst.29922
ISSN
0101-2061
Abstract
Hops (Humulus lupulus L. [Cannabaceae]), used to increase storage and palatability of food, exert various pharmacological effects, including sleep-promoting and antioxidant effects. Here, we evaluated the effects of Saaz, Saphir, Simcoe, and their mixtures on pentobarbital-induced sleep in mice and reactive oxygen species (ROS) production in H2O2-treated HT22 cells. Compared to administration of Saaz, Simcoe, and Saphir alone, the administration of Saaz/Saphir (75:25) and Simcoe/Saphir (50:50) mixtures resulted in slightly longer sleep durations in pentobarbital-administered mice. The Saaz/Saphir (75:25) group showed a longer sleep duration in the caffeine-induced insomnia model and slightly lower IC50 values for radicals than the Simcoe/Saphir (50:50) group. Xanthohumol present in hop mixtures suppressed ROS production and increased the expression of superoxide dismutase-1, catalase, and glutathione peroxidase-1 in H2O2-treated HT22 cells. Collectively, Simcoe/Saphir (50:50) and Saaz/Saphir (75:25) mixtures were more effective in removing ROS in brain cells and promoting sleep than hops alone.
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Suh, Hyung Joo
보건과학대학 (바이오시스템의과학부)
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