Naringenin and Phytoestrogen 8-Prenylnaringenin Protect against Islet Dysfunction and Inhibit Apoptotic Signaling in Insulin-Deficient Diabetic Mice
DC Field | Value | Language |
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dc.contributor.author | Park, Song | - |
dc.contributor.author | Sim, Kyu-Sang | - |
dc.contributor.author | Hwangbo, Yeop | - |
dc.contributor.author | Park, Sung-Jin | - |
dc.contributor.author | Kim, Young-Jun | - |
dc.contributor.author | Kim, Jun-Ho | - |
dc.date.accessioned | 2022-08-25T19:40:20Z | - |
dc.date.available | 2022-08-25T19:40:20Z | - |
dc.date.created | 2022-08-25 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/143380 | - |
dc.description.abstract | It has been shown that citrus flavanone naringenin and its prenyl derivative 8-prenylnaringenin (8-PN) possess various pharmacological activities in in vitro and in vivo models. Interestingly, it has been proposed that prenylation can enhance biological potentials, including the estrogen-like activities of flavonoids. The objective of this study was to investigate the anti-diabetic potential and molecular mechanism of 8-PN in streptozotocin (STZ)-induced insulin-deficient diabetic mice in comparison with naringenin reported to exhibit hypoglycemic effects. The oral administration of naringenin and 8-PN ameliorated impaired glucose homeostasis and islet dysfunction induced by STZ treatment. These protective effects were associated with the suppression of pancreatic beta-cell apoptosis and inflammatory responses in mice. Moreover, both naringenin and 8-PN normalized STZ-induced insulin-signaling defects in skeletal muscles and apoptotic protein expression in the liver. Importantly, 8-PN increased the protein expression levels of estrogen receptor-alpha (ER alpha) in the pancreas and liver and of fibroblast growth factor 21 in the liver, suggesting that 8-PN could act as an ER alpha agonist in the regulation of glucose homeostasis. This study provides novel insights into the mechanisms underlying preventive effects of naringenin and 8-PN on the impairment of glucose homeostasis in insulin-deficient diabetic mice. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | ESTROGEN-RECEPTOR-ALPHA | - |
dc.subject | PANCREATIC BETA-CELLS | - |
dc.subject | PI3K/AKT PATHWAY | - |
dc.subject | TYPE-1 | - |
dc.subject | ACTIVATION | - |
dc.subject | MECHANISMS | - |
dc.subject | FLAVANONE | - |
dc.subject | OBESITY | - |
dc.subject | MUSCLE | - |
dc.subject | DEATH | - |
dc.title | Naringenin and Phytoestrogen 8-Prenylnaringenin Protect against Islet Dysfunction and Inhibit Apoptotic Signaling in Insulin-Deficient Diabetic Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Young-Jun | - |
dc.identifier.doi | 10.3390/molecules27134227 | - |
dc.identifier.scopusid | 2-s2.0-85133425699 | - |
dc.identifier.wosid | 000823879300001 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.27, no.13 | - |
dc.relation.isPartOf | MOLECULES | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 27 | - |
dc.citation.number | 13 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | ESTROGEN-RECEPTOR-ALPHA | - |
dc.subject.keywordPlus | PANCREATIC BETA-CELLS | - |
dc.subject.keywordPlus | PI3K/AKT PATHWAY | - |
dc.subject.keywordPlus | TYPE-1 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | FLAVANONE | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | MUSCLE | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordAuthor | naringenin | - |
dc.subject.keywordAuthor | 8-prenylnaringenin | - |
dc.subject.keywordAuthor | diabetes | - |
dc.subject.keywordAuthor | islet dysfunction | - |
dc.subject.keywordAuthor | beta-cell apoptosis | - |
dc.subject.keywordAuthor | estrogen receptor-alpha | - |
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