Duration of Humoral Immunity and Cross-Neutralizing Activity Against the Alpha, Beta, and Delta Variants After Wild-Type Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Prospective Cohort Studyopen access
- Authors
- Noh, Ji Yun; Yang, Jeong-Sun; Hwang, Soon Young; Hyun, Hakjun; Seong, Hye; Yoon, Jin Gu; Yoon, Soo-Young; Cheong, Hee Jin; Kim, Woo Joo; Park, Woo-Jung; Kim, Jun-Won; Lee, Joo-Yeon; Song, Joon Young
- Issue Date
- 21-9월-2022
- Publisher
- OXFORD UNIV PRESS INC
- Keywords
- antibody; COVID-19; neutralizing activity; SARS-CoV-2; variants of concern
- Citation
- JOURNAL OF INFECTIOUS DISEASES, v.226, no.6, pp.975 - 978
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF INFECTIOUS DISEASES
- Volume
- 226
- Number
- 6
- Start Page
- 975
- End Page
- 978
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/145737
- DOI
- 10.1093/infdis/jiac050
- ISSN
- 0022-1899
- Abstract
- A prospective cohort study was conducted for adults with a diagnosis of with coronavirus disease 2019 (COVID-19). Convalescent blood samples were obtained 4, 6, and 11 months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The seropositivity of anti-spike antibody was maintained in all patients (100%) until 11 months after COVID-19 diagnosis. Neutralizing antibody levels against wild-type SARS-CoV-2 gradually decreased but remained positive in >50% of patients 11 months after diagnosis: in 98.5% (67 of 68) at 4 months, 86.8% (46 of 53) at 6 months, and 58.8% (40 of 68) at 11 months. However, cross-neutralizing activity against the Beta and Delta variants was attenuated 2.53-fold and 2.93-fold, respectively, compared with the wild-type strain. In convalescents with mild to moderate coronavirus disease 2019, neutralizing antibody levels against wild-type severe acute respiratory syndrome coronavirus 2 gradually decreased but remained positive in >50% of patients 11 months after diagnosis.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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