Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Olfactory Stimulation with Volatile Aroma Compounds of Basil (Ocimum basilicum L.) Essential Oil and Linalool Ameliorates White Fat Accumulation and Dyslipidemia in Chronically Stressed Ratsopen access

Authors
Kim, Da-SomHong, Seong-JunYoon, SojeongJo, Seong-MinJeong, HyangyeonYoun, Moon-YeonKim, Young-JunKim, Jae-KyeomShin, Eui-Cheol
Issue Date
5월-2022
Publisher
MDPI
Keywords
Ocimum basilicum L; essential oil; volatile compounds; linalool; stress lipid metabolism
Citation
NUTRIENTS, v.14, no.9
Indexed
SCIE
SCOPUS
Journal Title
NUTRIENTS
Volume
14
Number
9
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/145942
DOI
10.3390/nu14091822
ISSN
2072-6643
Abstract
We explored the physiological effects of inhaling basil essential oil (BEO) and/or linalool and identified odor-active aroma compounds in BEO using gas chromatography/mass spectrometry (GC-MS) and GC-olfactometry (GC-O). Linalool was identified as the major volatile compound in BEO. Three groups of rats were administered BEO and linalool via inhalation, while rats in the control group were not. Inhalation of BEO for 20 min only reduced the total weight gain (190.67 +/- 2.52 g) and increased the forced swimming time (47.33 +/- 14.84 s) compared with the control group (219.67 +/- 2.08 g, 8.33 +/- 5.13 s). Inhalation of BEO for 5 min (392 +/- 21 beats/min) only reduced the pulse compared with the control group (420 +/- 19 beats/min). Inhalation of linalool only reduced the weight of white adipose tissue (5.75 +/- 0.61 g). The levels of stress-related hormones were not significantly different among the groups. The total cholesterol and triglyceride levels decreased after inhalation of BEO for 20 min (by more than -10% and -15%, respectively). Low-density lipoprotein cholesterol levels were lowered (by more than -10%) by the inhalation of BEO and linalool, regardless of the inhalation time. In particular, BEO inhalation for 20 min was associated with the lowest level of low-density lipoprotein cholesterol (53.94 +/- 2.72 mg/dL). High-density lipoprotein cholesterol levels increased after inhalation of BEO (by more than +15%). The atherogenic index and cardiac risk factors were suppressed by BEO inhalation. Animals exposed to BEO and linalool had no significant differences in hepatotoxicity. These data suggest that the inhalation of BEO and linalool may ameliorate cardiovascular and lipid dysfunctions. These effects should be explored further for clinical applications.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Food and Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Young Jun photo

Kim, Young Jun
식품생명공학과
Read more

Altmetrics

Total Views & Downloads

BROWSE