Diterpenoids and Diacetylenes from the Roots of Aralia cordata with Inhibitory Effects on Nitric Oxide Production
- Authors
- Kim, Jun Gu; Lee, Jin Woo; Thi Phuong Linh Le; Han, Jae Sang; Kwon, Haeun; Lee, Dongho; Hong, Jin Tae; Kim, Youngsoo; Lee, Mi Kyeong; Hwang, Bang Yeon
- Issue Date
- 26-2월-2021
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.84, no.2, pp.230 - 238
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 84
- Number
- 2
- Start Page
- 230
- End Page
- 238
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/49544
- DOI
- 10.1021/acs.jnatprod.0c00842
- ISSN
- 0163-3864
- Abstract
- Bioactivity-guided isolation of a MeOH extract of Aralia cordata led to the isolation of four new ent-pimarane diterpenoids (1-4) and a diacetylene (5) together with 21 known compounds (6-26). Their structures were established based on the interpretation of one- and two-dimensional NMR and HRESIMS data. The absolute configurations of the new isolates were determined by electronic circular dichroism data analysis, single crystal X-ray diffraction, and Mosher's esterification method. All compounds exhibited inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages with IC50 values ranging from 1.1 to 69.4 mu M.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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