Characterization of HIV-1 recombinant and subtype B near full-length genome among men who have sex with men in South Korea
- Authors
- Ryou, Sangmi; Yoo, Myeongsu; Kim, Kisoon; Kim, Sangsoo; Kim, Sang Il; Kim, Youn Jeong; Park, Dae Won; Choi, Jun Yong; Kim, Hyo Youl; Kim, Jung Ho; Song, Joon Young; Kim, Shin-Woo; Chang, Hyun-Ha; Choi, Bo Youl; Kee, Mee-Kyung
- Issue Date
- 18-2월-2021
- Publisher
- NATURE RESEARCH
- Citation
- SCIENTIFIC REPORTS, v.11, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 11
- Number
- 1
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/49560
- DOI
- 10.1038/s41598-021-82872-3
- ISSN
- 2045-2322
- Abstract
- In Korea, subtype B is the predominant variant of HIV-1, but full genome sequencing and analysis of its viral variants are lacking. We performed near full-length genome (NFLG) sequencing and phylogenetic and recombination analyses of fifty plasma samples from HIV-positive men who have sex with men (MSM) from a Korea HIV/AIDS cohort study. Viral genomes were amplified and the near-full-length sequences were determined using next-generation sequencing (NGS) and Sanger sequencing. We focused on the HIV-1 subtype classification and identification of HIV recombinants. Twelve HIV-1 NFLGs were determined: ten were subtyped as pure HIV-1 subtype B and two recombinant strains as a common subtype CRF07_BC, and a novel subtype CRF43_02G recombined with CRF02_AG again, or a new CRF02_AG and subtype G recombinant. For the ten NFLGs determined by NGS, "the novel recombinant emerged at approximately 2003 and the other nine subtype B about 2004 or 2005". This is the first report analyzing HIV-1 NFLG, including recombinants and clinical characteristics, by subtype among MSM in Korea. Our results provide novel insights for understanding the recombinants in the HIV-1 epidemic in Korea.
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