Osthole interacts with an ER-mitochondria axis and facilitates tumor suppression in ovarian cancer
- Authors
- Bae, Hyocheol; Lee, Jin-Young; Song, Jisoo; Song, Gwonhwa; Lim, Whasun
- Issue Date
- 2월-2021
- Publisher
- WILEY
- Keywords
- apoptosis; calcium homeostasis; osthole; ovarian cancer; zebrafish
- Citation
- JOURNAL OF CELLULAR PHYSIOLOGY, v.236, no.2, pp.1025 - 1042
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CELLULAR PHYSIOLOGY
- Volume
- 236
- Number
- 2
- Start Page
- 1025
- End Page
- 1042
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/49663
- DOI
- 10.1002/jcp.29913
- ISSN
- 0021-9541
- Abstract
- Osthole is a natural coumarin found in a variety of plants and has been reported to have diverse biological functions, including antimicrobial, antiviral, immunomodulatory, and anticancer effects. Here, we investigated the natural derivative osthole as a promising anticancer compound against ovarian cancer and evaluated its ability to suppress and abrogate tumor progression. In addition, we found the endoplasmic reticulum-mitochondrial axis-mediated anticancer mechanisms of osthole against ES2 and OV90 ovarian cancer cells and demonstrated its calcium-dependent pharmacological potential. Mechanistically, osthole was found to target the phosphatidylinositol 3-kinase/mitogen-activated protein kinase signaling pathway to facilitate tumor suppression in ovarian cancer. Furthermore, we identified the effects of osthole in a three-dimensional tumor-formation model using the zebrafish xenograft assay, providing convincing evidence of the pharmacological effects of osthole within the anchorage-independent tumor microenvironment. These findings suggest that osthole has strong potential as a pharmacological agent for targeting ovarian cancer.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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