Clinical implication of tumour spread through air spaces in pathological stage I lung adenocarcinoma treated with lobectomy
- Authors
- Yi, Eunjue; Lee, Jeong Hyeon; Jung, Younggi; Chung, Jae Ho; Lee, Youngseok; Lee, Sungho
- Issue Date
- 1월-2021
- Publisher
- OXFORD UNIV PRESS
- Keywords
- Invasive adenocarcinoma; Lobectomy; Prognosis
- Citation
- INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, v.32, no.1, pp.64 - 72
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
- Volume
- 32
- Number
- 1
- Start Page
- 64
- End Page
- 72
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/50626
- DOI
- 10.1093/icvts/ivaa227
- ISSN
- 1569-9293
- Abstract
- OBJECTIVES: The aim of this study was to evaluate the clinical implication of tumour spread through air spaces (STAS) as a prognostic factor in pathological stage I lung adenocarcinoma treated with lobectomy and to identify related parameters. METHODS: Medical records of patients who underwent pulmonary lobectomy for stage I (American Joint Committee on Cancers eighth edition) lung adenocarcinomas between 2012 and February 2018 at our institutions were reviewed retrospectively. Patients with minimally invasive adenocarcinomas and tumours >3 cm in size were excluded. Included patients were classified into STAS (+) and STAS (-) groups. Clinical implications of STAS and recurrence in patients were investigated. RESULTS: A total of 109 patients was analysed: 41 (37.6%) in the STAS (+) and 68 (62.4%) in the STAS (-) group. STAS was associated with larger consolidation diameter on chest tomography (>= 1.5 cm; P = 0.006) or a higher invasive ratio (>= 85%; P = 0.012) and presence of a micropapillary pattern in multivariable analysis (P = 0.003) The recurrence-free survival curve showed statistical difference (P = 0.008) with 3-year survival rates of 73.0% (9 patients) and 96.8% (2 patients) in the STAS (+) and STAS (-) group, respectively. However, no statistical significance was observed in the lung cancer-related survival curve (P = 0.648). The presence of STAS was an independent risk factor for recurrence in multivariable analysis (hazard ratio = 5.9, P = 0.031). CONCLUSIONS: The presence of STAS could be an important risk factor for recurrence in patients with early-stage invasive lung adenocarcinoma treated with pulmonary lobectomy.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.