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Phenotypic Discovery of an Antivirulence Agent against Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR
- Authors
- Kim, Seung Min; Park, Jongmin; Kim, Myun Soo; Song, Heebum; Jo, Ala; Park, Hankum; Kim, Tae Sung; Choi, Sang Ho; Park, Seung Bum
- Issue Date
- 13-Nov-2020
- Publisher
- AMER CHEMICAL SOC
- Keywords
- antivirulence agent; Vibrio vulnificus; SmcR; target identification; quorum sensing
- Citation
- ACS INFECTIOUS DISEASES, v.6, no.11, pp.3076 - 3082
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS INFECTIOUS DISEASES
- Volume
- 6
- Number
- 11
- Start Page
- 3076
- End Page
- 3082
- ISSN
- 2373-8227
- Abstract
- An antivirulence agent against Vibrio vulnificus named quoromycin (QM) was discovered by a phenotype-based elastase inhibitor screening. Using the fluorescence difference in two-dimensional gel electrophoresis (FITGE) approach, SmcR, a quorum-sensing master regulator and homologue of LuxR, was identified as the target protein of QM. We confirmed that the direct binding of QM to SmcR inhibits the quorum-sensing signaling pathway by controlling the DNA-binding affinity of SmcR and thus effectively alleviates the virulence of V. vulnificus in vitro and in vivo. QM can be regarded as a novel antivirulence agent for the treatment of V. vulnificus infection.
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Related Researcher
- Kim, Tae Sung
- Department of Life Sciences