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Cited 9 time in webofscience Cited 4 time in scopus
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Glycated milk protein fermented withLactobacillus rhamnosusameliorates the cognitive health of mice under mild-stress condition

Authors
Oh, Nam SuJoung, Jae YeonLee, Ji YoungSong, Jae GwangOh, SangnamKim, YounghoonKim, Hyung WookKim, Sae Hun
Issue Date
1-11월-2020
Publisher
TAYLOR & FRANCIS INC
Keywords
Chronic mild stress; brain-gut-microbiome axis; casein; glycation
Citation
GUT MICROBES, v.11, no.6, pp.1643 - 1661
Indexed
SCIE
SCOPUS
Journal Title
GUT MICROBES
Volume
11
Number
6
Start Page
1643
End Page
1661
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/51844
DOI
10.1080/19490976.2020.1756690
ISSN
1949-0976
Abstract
This study aimed to investigate the effects of glycated milk casein (Gc) fermented withLactobacillus rhamnosus4B15 (FGc) on the intestinal microbiota and physiological and behavioral properties in mice under chronic stress. Mice were administered Gc or FGc for 10 weeks and then exposed to unpredictable chronic mild stress (UCMS) for 7 weeks. FGc administration restored alterations of gut microbiota induced by UCMS. Moreover, FGc significantly reduced the stress-induced increase in serum corticosterone and decrease in serotonin levels. Anxiety-like behaviors induced by UCMS were also significantly decreased in the FGc group. UCMS-induced dysregulation of gene and protein expression related to neuroendocrine function, neuronal development, and inflammation, and gut-blood-brain barrier function was controlled by FGc pre-treatment. These results strongly suggest the protective effects of FGc targeting of intestinal microbiota for abnormal brain activity, which is consistent with the view that FGc plays an important role in regulating stress-related gut-brain axis disorders.
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