Emerging roles of 14-3-3 gamma in the brain disorder
- Authors
- Cho, Eunsil; Park, Jae-Yong
- Issue Date
- 31-10월-2020
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- Keywords
- 14-3-3 gamma; 14-3-3 protein; 14-3-3 gamma; Brain disorders; Glioma; Inflammatory disease; Neurodegenerative disease; Neurodevelopmental disease; YWHAG
- Citation
- BMB REPORTS, v.53, no.10, pp.500 - 511
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BMB REPORTS
- Volume
- 53
- Number
- 10
- Start Page
- 500
- End Page
- 511
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/52087
- DOI
- 10.5483/BMBRep.2020.53.10.158
- ISSN
- 1976-6696
- Abstract
- 14-3-3 proteins are mostly expressed in the brain and are closely involved in numerous brain functions and various brain disorders. Among the isotypes of the 14-3-3 proteins, 14-3-3 gamma is mainly expressed in neurons and is highly produced during brain development, which could indicate that it has a significance in neural development. Furthermore, the distinctive levels of temporally and locally regulated 14-3-3 gamma expression in various brain disorders suggest that it could play a substantial role in brain plasticity of the diseased states. In this review, we introduce the various brain disorders reported to be involved with 14-3-3 gamma, and summarize the changes of 14-3-3 gamma expression in each brain disease. We also discuss the potential of 14-3-3 gamma for treatment and the importance of research on specific 14-3-3 isotypes for an effective therapeutic approach.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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