Emerging roles of 14-3-3 gamma in the brain disorder

Abstract

14-3-3 proteins are mostly expressed in the brain and are closely involved in numerous brain functions and various brain disorders. Among the isotypes of the 14-3-3 proteins, 14-3-3 gamma is mainly expressed in neurons and is highly produced during brain development, which could indicate that it has a significance in neural development. Furthermore, the distinctive levels of temporally and locally regulated 14-3-3 gamma expression in various brain disorders suggest that it could play a substantial role in brain plasticity of the diseased states. In this review, we introduce the various brain disorders reported to be involved with 14-3-3 gamma, and summarize the changes of 14-3-3 gamma expression in each brain disease. We also discuss the potential of 14-3-3 gamma for treatment and the importance of research on specific 14-3-3 isotypes for an effective therapeutic approach.