Visualizing mitochondria and mouse intestine with a fluorescent complex of a naphthalene-based dipolar dye and serum albumin
- Authors
- An, Jong Min; Moon, Heejo; Kim, Yejin; Kang, Sangrim; Kim, Youngseo; Jung, Yuna; Park, Sungnam; Verwilst, Peter; Kim, B. Moon; Kang, Jae Seung; Kim, Dokyoung
- Issue Date
- 14-9월-2020
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- JOURNAL OF MATERIALS CHEMISTRY B, v.8, no.34, pp.7642 - 7651
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF MATERIALS CHEMISTRY B
- Volume
- 8
- Number
- 34
- Start Page
- 7642
- End Page
- 7651
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/53166
- DOI
- 10.1039/d0tb01314e
- ISSN
- 2050-7518
- Abstract
- We have explored a new research field of fluorophores through the manipulation of fluorophore-binding proteins. The development of a new imaging agent for tracing a specific organelle or a particular site within a living organism has been of great interest in the field of basic science as well as translational medicine. In this work and for the first time, we will disclose a new naphthalene-based dipolar dye and its complex, with serum albumin (SA), and show their applicability for the selective imaging of mitochondria in cells and the intestine in a mouse. The SA-binding dipolar dye, IPNHC, was synthesized straightforwardly, and we identified its photophysical properties and binding mode with SA. IPNHC-SA complex showed a bright emission in the blue wavelength range with a high quantum yield and stability. In the fluorescence imaging study, bright fluorescence images of mouse intestines were observed under a UV light, as well as two-photon (TP) deep tissue imaging after intravenous injection of IPNHC and IPNHC-SA complex. The present findings hold great promise for the application of the fluorescent complex for use in the tracing and tracking of intestine-related diseases at clinical sites.
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