Reirradiation with intensity-modulated radiation therapy for recurrent or secondary head and neck cancer: Meta-analysis and systematic review
- Authors
- Lee, Jeongshim; Shin, In-Soo; Kim, Woo C.; Yoon, Won S.; Koom, Woong S.; Rim, Chai H.
- Issue Date
- 9월-2020
- Publisher
- WILEY
- Keywords
- head and neck cancer; intensity-modulated radiotherapy; meta-analysis; recurrence; reirradiation
- Citation
- HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v.42, no.9, pp.2473 - 2485
- Indexed
- SCIE
SCOPUS
- Journal Title
- HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- Volume
- 42
- Number
- 9
- Start Page
- 2473
- End Page
- 2485
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/53263
- DOI
- 10.1002/hed.26264
- ISSN
- 1043-3074
- Abstract
- Background To summarize outcomes of reirradiation with intensity-modulated radiotherapy (IMRT) for recurrent or secondary head and neck cancer (HNC). Methods Primary endpoints were 2-year local control (LC) and overall survival (OS). Studies involving only recurrent nasopharyngeal patients with cancer were excluded. Results A total of 17 studies involving 1635 patients were included. Fourteen (82%) of those were retrospective, and 15 (88%) were from single institution. Reirradiation with IMRT produced pooled 2-year LC and OS rates of 52% (95% confidence interval [CI], 46%-57%) and 46% (95% CI, 41%-50%), respectively. In subgroup analyses, the rate of salvage surgery (<42% vs >= 42%) influenced the pooled 2-year LC rate (45.9% vs 58.5%, P = .011). The pooled rates of late grade >= 3 and grade 5 toxicities were 26% (95% CI, 20%-32%) and 3.1% (95% CI, 2%-5%), respectively. Conclusions Reirradiation with IMRT was an effective modality compared to historical outcomes in the pre-IMRT era.
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