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Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha
- Authors
- Liu, Wenpei; Song, Ziteng; Wang, Huimei; Yang, Xueyuan; Joubert, Elizabeth; Zhang, Jie; Li, Shen; Tuerhong, Muhetaer; Abudukeremu, Munira; Jin, Jin; Xu, Jing; Lee, Dongho; Guo, Yuanqiang
- Issue Date
- 8월-2020
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Nitric oxide inhibitory effects; Ajuga pantantha; Diterpenoids; Inflammation; Molecular docking; Zebrafish model
- Citation
- BIOORGANIC CHEMISTRY, v.101
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC CHEMISTRY
- Volume
- 101
- ISSN
- 0045-2068
- Abstract
- A phytochemical survey to obtain bioactive natural products from Ajuga pantantha afforded five new neo-cler-odane diterpenoids (1-5). The structures were established by analysis of their NMR spectroscopic data, and electronic circular dichroism calculations were applied to define their absolute configurations. Compounds 2 and 5 were found to have the property of inhibiting NO production (IC50 values < 40 mu M). Molecular docking and Western blotting were used to study the mechanism of anti-inflammatory action. Furthermore, compound 5 with the highest activity was tested for its in vivo anti-inflammatory effects using a zebrafish model.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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