A Prospective Randomized Clinical Trial of Combination Therapy with Proton Pump Inhibitors and Mucolytics in Patients with Laryngopharyngeal Reflux
- Authors
- Chae, Minsuk; Jang, Dong Hyuk; Kim, Ho Chan; Kwon, Minsu
- Issue Date
- 8월-2020
- Publisher
- SAGE PUBLICATIONS INC
- Keywords
- ambroxol-theophyllin-7-acetate; globus sensation; laryngopharyngeal reflux; expectorants; proton pump inhibitors
- Citation
- ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, v.129, no.8, pp.781 - 787
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
- Volume
- 129
- Number
- 8
- Start Page
- 781
- End Page
- 787
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/54246
- DOI
- 10.1177/0003489420913592
- ISSN
- 0003-4894
- Abstract
- Objectives: To identify whether combination therapy with mucolytics and proton pump inhibitors (PPIs) leads to faster and more effective symptomatic relief in patients with laryngopharyngeal reflux (LPR). Methods: Patients diagnosed as LPR with a reflux symptom index (RSI) >= 13 and a reflux finding score (RFS) >= 7 were enrolled in this prospective study. Patients were randomly allocated to control (PPI only) or experimental (PPI + mucolytics) groups and changes in RSI and RFS values were assessed at 1- and 3-month follow-up. Results: One hundred sixteen patients were randomly allocated into either the control group (n = 59) or the experimental group (n = 57). The RSI and RFS scores significantly decreased in both groups (all P < .001) after 1 month of treatment; however, there was no significant difference in RSI change between groups (P = .223). After 3 months of treatment, there remained no significant difference in RSI change between groups (P = .592). Conclusions: Combination therapy with mucolytics and PPI compared to PPI alone did not lead to faster or more effective symptomatic relief in LPR patients.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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